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Although the specific DNA lesions were not identified, the heightened vulnerability of mtDNA was further supported by experiments using isolated mitochondria, where blue light exposure led to a time-dependent increase in ROS production, such as O 2 , 1 O 2 and OH

To position CBS upstream of cysteine and GSH

Measurement of lipid peroxidation and glutathione levels The levels of malondialdehyde (MDA), an indicator of lipid peroxidation, were measured in myocardial tissue (100150 mg) by using a commercially available kit (Bioxytech, MDA-586TM assay, Oxis International Inc., Foster City, CA)

Glutathione is an antioxidant that helps to protect the cells from damage

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