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CM has been shown to alter the hypothalamicpituitaryadrenal (HPA) axis response to stress, leading to modified DNA methylation of the glucocorticoid receptor ( NR3C1 ) and BDNF genes, which in turn increases susceptibility to schizophrenia (Figure 6D)

Cell 56 , 414424 (2014)

The protocol structure is more cycle-based than daily-continuous: a defined number of injection days followed by scheduled rest periods

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer's Disease

Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation