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Regarding expression and activity, the knowledge about the regulation of carriers and enzymes that modulate -oxidation in cancer cells is of extreme interest since their inhibition may significantly affect the tumorigenic potential even in the presence of compensatory metabolic pathways

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Inherited defects of fatty acids oxidation are transmitted as autosomal recessive traits in humans, and more than thirty inherited metabolic diseases can be identified by screening for the presence of acylcarnitines in the blood and urine of new-born infants, although thankfully none of these is common (1 in ~10,000 live births), and that found most often is medium-chain acyl-CoA dehydrogenase deficiency

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PMID: [PubMed] [Google Scholar] 35.Fielding R, Riede L, Lugo JP, Bellamine A

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