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10.1016/j.ijbiomac.2016.05.106 Int

HO-1 can degrade haem into ferrous iron, and overexpression of HO-1 can alleviate hypertrophy, fibrosis and oxidative stress in a failing heart and promote neovascularization [116]

Anti-ferroptotic genes, including SLC7A11 and HO-1, which support cellular survival, have their transcription activated by Nrf2

This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system

To produce a THC-rich oil (APEPI) they use a transgenic strain of Cannabis , that produces a higher amount of THC compared to other cannabinoids
