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Methods A non-systematic literature search was performed on PubMed using as search terms (acetyl-l-carnitine OR L-acetylcarnitine OR ALCAR) in conjunction with one of the following: nerve damage, neuropathy, peripheral neuropathy, radiculopathy, neuropathic pain, diabetic polyneuropathy, chemotherapy-induced polyneuropathy, carpal tunnel syndrome, Fabry disease

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Elevated circulating IGF-1 led to an activation of the IGF-1PI3KAkt signalling pathway, causing augmented mTOR phosphorylation and higher phospho-FoxO/total FoxO ratio in skeletal muscle of LC supplemented rats [33]