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In PD, this pathway is often disrupted due to IR in the brain

Cellular zinc homeostasis is intricately controlled by a complex network of proteins, encompassing the solute carrier (SLC) families SLC30 (ZnT) and SLC39 (Zrt- and Irt-like proteins/ZIP), in addition to zinc-binding metallothioneins (MTs) (Chen et al., 2024[76]

Indeed, overproduction of ROS is known to be crucial for carcinogenesis by promoting DNA oxidative damage, more specifically base alterations, abasic sites, and strand breaks [15]

Furthermore, it is reinforced that after being surgically resected, primary intestinal DLBCL with high c-MET copy numbers was associated with an unfavorable prognosis [19]

Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, et al

, do M., Fortenberry D., Billings R., Sartayev A., and Tyler W