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In the ferroptotic process, iron plays a pivotal role in several processes, including Fenton reaction-driven ROS production and the activation of key enzymes involved in lipid peroxidation, such as ALOX, NOX, and mitochondrial complexes I and III [103]

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It activates the MAPK/ERK signaling pathway, which tells fibroblasts (the cells that produce collagen) to ramp up production

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Guilfoyle MR, Helmy A, Donnelly J, Stovell MG, Timofeev I, Pickard JD, et al
