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Pushing doses up too fast is the single biggest cause of dropping out
This was first demonstrated by an in vitro study in which the treatment of HUVECs with a Cu chelator, tetraethylenepentamine (TEPA), suppressed the expression of a group of HIF-1 target genes such as BNIP3 and VEGF, but did not affect other HIF-1 target genes such as IGF-2 [132]

This remains anecdotal rather than research-validated but worth considering for those who track cycles
[32] develop a consensus-based TES design managed by an Independent Distribution System Operator (IDSO) for an unbalanced LV distribution grid electrically connected to an HV transmission grid

Int Immunopharmacol 28(2):859865 Liu R, Liu J, Huang Q, Liu S, Jiang Y (2022) Moringa oleifera : a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity
- (CosMos Academy)