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Acknowledgements Authors wish to thank Molecular Medicine Department and also Pharmaceutical Sciences Research Center of Shiraz University of Medical Sciences

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[40] N-Acetylcysteine as a Glutathione Regenerator N-acetylcysteine has been used successfully to treat hepatic and renal failure caused by glutathione depletion secondary to acetaminophen overdose

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The mechanisms include reduced oxidative stress in the gut wall, normalization of intestinal blood flow via the NO system, and modulation of inflammatory cytokine activity