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Inhibition of ferroptosis or downregulation of ACSL4 expression significantly improves clinical symptoms, reduces neuronal death, and alleviates neuroinflammation (Van San et al., 2023)

Trx plays an important role in the treatment of COPD (Fig

Zou Y, Henry WS, Ricq EL, Graham ET, Phadnis VV, Maretich P, Paradkar S, Boehnke N, Deik AA, Reinhardt F, Eaton JK, Ferguson B, Wang W, Fairman J, Keys HR, Dancik V, Clish CB, Clemons PA, Hammond PT, Boyer LA, Weinberg RA, Schreiber SL (2020) Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Differences in expression of GSTP1 may affect the response of patients with ovarian cancer to platinum-based chemotherapy (32)

Brain sex-dependent alterations after prolonged high fat diet exposure in mice

Liver cirrhosis complicated with infection is also prone to septic shock, which can lead to multiple organ failure, leading to liver dysfunction, liver cell damage, and eventually liver failure and death (Hsu et al., 2021)