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Thats the metaphor, Martin explains

But once you add water back, freezing creates ice crystals that can physically disrupt the peptide molecules

Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen

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Progressive renal failure and blindness due to retinal hemorrhage after interferon therapy for hepatitis C virus-associated membranoproliferative glomerulonephritis
[2] [3] [4] [5] [6] [Reaction Scheme 1] [7] enzyme [8] wherein R is an alkyl group (C H , n = 1 to 8)