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When this pattern is observed consistently across multiple injections, copper sensitivity is the first thing evaluated and the primary reason protocols are adjusted or discontinued

If adjustments to pH are necessary for your research, test the peptides stability under those conditions before proceeding with your study

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Dietary copper, mainly in the Cu 2+ (cupric) form, is absorbed in the duodenum and proximal small intestine

They are also necessary for the interconversion of amino acids such as the metabolism of histidine to glutamic acid and the interconversion of serine and glycine

Onset is typically abrupt