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4 Discussion Recent studies strongly indicate that antioxidant supplementation alone modifies the sperm epigenome, suggesting disruptions in male redox health, generally, may induce paternal effects on offspring development ( reviewed (Moazamian et al., 2025))

On the other hand, moderate hyperhomocysteinemia induces immune activation through ROS and oxidative stress (Schroecksnadel et al

Supplementary information 41598_2019_54065_MOESM1_ESM.docx (download DOCX The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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[PubMed] [Google Scholar] 17.Mutlib AE, Goosen TC, Bauman JN, Williams JA, Kulkarni S, et al