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Furthermore, it promotes the polarization of microglia from the pro-inflammatory M1 phenotype (indicated by a decrease in the CD86 + ratio) to the anti-inflammatory M2 phenotype (indicated by an increase in the CD206 + ratio)
Systemic sclerosis and Raynauds phenomenon
In short, its found virtually everywhere in the human body, and its essential to our healthy existence
[11] and Lardinois [12]
Low-dose oxidative stress triggers a conformational change in the Keap1 protein, releasing the transcription factor Nrf2
