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RPE1 (ATCC, CRL-4000), HEK293T (ATCC, CRL-3216) and Lenti-X 293T (Takara Bio, 632180) cells were cultured in 10% FBS in DMEM

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DNA molecules that overlapped as wells as dots at the end of the DNA molecule which could have resulted from DNA strand breaks during the DNA extraction process were excluded from the analysis

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