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Lunn JS, Hefferan MP, et al

In 2025, a recent study of Hu et al

Polmacoxib is an orally active dual inhibitor of COX-2 and carbonic anhydrase (CA)

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Signs of Gut-Related Acne: Bloating, constipation, or diarrhea Food sensitivities Brain fog or fatigue Acne flares after antibiotics or sugary meals Functional Testing: Gut Zoomer stool testing Organic Acids Test (for yeast markers like arabinose) Treatment Strategies: Repair leaky gut with: Rebalance microbiome : Broad-spectrum probiotic Consider yeast-killing protocols if fungal markers are high Peptide option : LL-37 for antimicrobial immune support, particularly if acne is driven by microbial overgrowth or skin infections
