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Similarly, defects in CMA led to reduced lipid metabolism, impaired clotting function, decreased VSMC resistance to lipid toxicity and increased dedifferentiation processes in mice, thereby further elevating the risk of atherosclerosis (199)

Besides, TQ enhanced chemosensitivity to chemotherapeutics and chemopreventive molecules by downregulating inflammatory signaling pathways and enhancing tumor-suppressing genes [116,118,120,300]

Conversely, individuals diagnosed with depression are found to be at increased risk for developing NAFLD (274)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Begaye B, Vinales KL, Hollstein T, Ando T, Walter M, Bogardus C, Krakoff J, Piaggi P
