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In vitro experiments demonstrated that ESM1 promoted drug resistance, proliferation, migration, invasion and epithelial-mesenchymal transition through HIF-1 in A549 and PC-9 non-small cell lung cancer cells following intermittent hypoxia (79)

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Into, T., Inomata, M., Shibata, K., and Murakami, Y., Cell

An optimal time point for such early diagnosis, as illustrated in Figure 2 (the hypothetical golden hours), might be instrumental in screening patients with a higher risk of progressing to DHF

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