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This increase was partially blocked by GSK-7975A (Figures 2E, 3C)

When neurofibromin is absent or non-functional, RAS remains constitutively active, driving downstream MEK/ERK pathway hyperactivation and uncontrolled cell proliferation

The samples were centrifuged (13,400 rpm) for 30 min, and the supernatant was collected and filtered (0.2 m syringe filter) into an LCMS vial

NFB, a transcription factor, is a pivotal mediator of inflammatory responses, while inflammasomes, such as members of NOD-like receptor family, including NLRC5 and NLRP, play a key role in sensing inflammatory signals and triggering the innate immune response 56

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