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Selenium is required for glutathione peroxidase (GPx) which converts potentially harmful hydrogen peroxide into water leaving behind oxidized glutathione (GSSG)

Synthesis: Rate-limiting enzyme is Glutamate Cysteine Ligase (GCL)

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Other significant risk factors that may be linked to cognitive impairment include increased oxidative stress and inflammation [74], decreased physical activity [75], peripheral vascular disease [76], high or low blood pressure (non-normotensive patients) [77], elevated intracranial pressure linked to the narrowing of blood vessels in the brain [78], coexisting comorbidities [79], tobacco use [80], and genetic predisposition [81]

J Strength Cond Res 37(7):e413e421 Wang Y et al (2023) Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training

Next, the synergistic effects of CBD, 19 , and 21 in combination with cisplatin at various concentrations were evaluated by determining their combination index (CI)