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Description
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Cardiovascular complications, including cardiomyopathy and structural cardiac remodelling, appear to represent the most clinically significant outcomes, as comprehensively described by Iliakis and Stamou (90)
Upon inhalation, PAHs are bioactivated by cytochrome P450 (CYP450) enzymes, converting them into highly reactive electrophiles such as diol-epoxides and redox-active quinones
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Key point
These findings indicate that hepatic toxicity associated with anabolicandrogenic steroid use can be severe and, in some cases, life-threatening (75)
