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Vitamin B12 (B12) is an essential cofactor for two enzymes involved in onecarbon metabolism: methylmalonyl CoA mutase (reduced function of this enzyme results in increased serum methylmalonyl acid (MMA) levels) and methionine synthetase (this enzyme catalyzes the remethylmation of homocysteine to methionine)
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acknowledges support from the Canadian Institutes of Health Research (RN192747-298730) and Diabetes Canada (RN271389-OG-3-15-5025-DZ)
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