glutathione s-transferase alpha 2 The role of S-transferases in human disease pathogenesis and their current inhibitors Dual localization of glutathione S‐transferase

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Karandikar-Iyer, S

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MDM2 mediates the ubiquitin-dependent degradation of SPY1, resulting in a downregulation of SPY1 expression, which in turn upregulates the expression of ALOX15 and growth differentiation factor 15 (GDF15), while decreasing the levels of GCH1, GPX4, and GSH

In turn, there was a significant improvement in certain behavioral deficits including cognitive decline and depressive-like behavior