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Two isozymes of ACC are present in mammals, ACC1, which is present in the cytosol, and ACC2, which is located at the mitochondrial membrane (101, 102)

doi: 10.1038/s41598-020-66460-5 39 LiX.ZhangM.HeL.ZhouJ.ShenP.DaiW.et al

Shadi Mehraban, Sepide Nematian, Shadan S Mehraban, Samantha Petrucci, Gabrielle Tricoricio, Zarina Parnas, Lenny Shats, Tomi Kanninen, Michael Moretti, Michael Cabbad, Nisha Lakhi

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2020;192(46):E145368

They are being developed as drugs for the treatment of excessive inflammatory responses to infections with gram-negative bacteria