cpt for vitamin b12 injection CYANOCOBALAMIN INJECTION, USP 30000 mcg/30 mL (1000 mcg/mL) 30 mL VIAL Vitamin Injections Des Plaines, IL

Adverse Effects of Vitamin B12 Preservative hypersensitivity the phenol in injectable solutions can cause rash, fever and urticaria

Typical starting doses range from 0.5 g to 2 g (10 - 40 mL of the 50 mg/mL solution) given intermittently (e.g., weekly)

Vitamin B12 There is four types of parenteral Vitamin B12 available: Cyanocobalamin 100 mcg/ml and 1000 mcg/ml best used as IM to prevent rapid loss via kidneys Hydroxycobalamin IM (compounded 1000 mcg/ml or more) known as long acting B12 (binds better to plasma proteins than cyanocobalamin) Methylcobalamin IV (compounded 1000 mcg or more up to 5000 mcg/ml) Adenosylcobalamin IV Common dose is 1000 mcg IM or IV Vitamin B12 as hydroxycobalamin is synthesized exclusively by microorganisms and is found in the liver of animals bound to protein as methylcobalamin = metabolically active form of Vitamin B12 Hydroxycobalamin is a chelator of cyanide and is used in cyanide poisoning Hydroxocobalamin is most generally used for vitamin B12 replacement therapy and is considered the drug of choice for vitamin B12 deficiency by the Martindale Extra Pharmacopoeia (Sweetman, 2002) and the World Health Organization (WHO) Model List of Essential Drugs

Our experience shows that while GHK-Cu is extensively studied for broad-spectrum skin and wound healing applications, AHK-Cu is carving out a formidable niche in more specialized areas

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