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It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent

[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Bhattacharya P, Chekmenev EY, Perman WH, Harris KC, Lin AP, Norton VA, Tan CT, Ross BD, Weitekamp DP