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Accordingly, the optimal strategy should be regarded as a biomarker-specific, application-driven selection

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10.3390/ijms24065238 9 Al-ChalabiA.HardimanO

This decision follows a comprehensive review of data demonstrating that when BHRT is initiated during the "therapeutic window", typically within 10 years of menopause onset or before age 60, the benefits for symptom relief, bone density preservation, and cardiovascular protection often outweigh the risks

doi: 10.2174/0929867325666171129124616