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24 These growth factors induce proliferation of keratinocytes and fibroblasts, lead to new formation of capillaries in the granulation tissue, and modulate extracellular matrix deposition and reconstitution of the injured area

The enzymatic antioxidants like superoxide dismutase, catalase, peroxiredoxins and peroxidases are involved in ROS degradation

The animals were subdivided into seven groups of six animals each: group 1 (normal rats), group 2 (normal+D-limonene [200 mg/kg BW]), group 3 (diabetic rats), group 4 (diabetic+D-limonene [50 mg/kg BW]), group 5 (diabetic+ D-limonene [100 mg/kg BW]), group 6 (diabetic+ D-limonene [200 mg/kg BW]), and group 7 (diabetic+ glibenclamide [600 g/kg])

FIGURE 2 3.1 Subcellular dysfunction and oxidative stress 3.1.1 Mitochondria and oxidative stress Mitochondrial dysfunction plays a critical role in the pathogenesis of BIPN

An improved capillary electrophoresis method for measuring tissue metabolites associated with cellular energy state

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