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In the Alzheimers disease model, GLPs activate FGFR1 and its downstream ERK/AKT pathways, promoting the proliferation of Ki67 + SOX2 + hippocampal neural progenitor cells and the generation of BrdU + NeuN + new neurons

The effect of total glutathione depletion on NO-initiated toxicity in HA1 cells was dose- and cell-density dependent and was observed to occur within 5 min of exposure to NO

Considering the high intracellular concentrations, GSH acts as a potent antioxidant against a variety of ROS, while GSH depletion is caused by increased oxidative stress and/or decreased GSH synthesis, especially in neurons, which are more vulnerable to ROS than are glial cells [5]

doi: 10.1007/s11064-021-03335-9 47

The levels of MDA, SOD and CAT were determined using Total Superoxide Dismutase Assay (Beyotime Institute of Biotechnology), Catalase Assay (Beyotime Institute of Biotechnology) and Malondialdehyde Detection (Beijing Solarbio Science & Technology Co., Ltd.) according to the manufacturer's instructions

Although they are easy to find and use, glutathione in pill form is absorbed poorly and has lower efficacy than when injected