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however, their bioavailability is low,22 and long term efficacy studies in symptomatic B 12 deficiency are lacking

For patients seeking modest metabolic support rather than dramatic fat reduction, they may serve a complementary role

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It also has a role in producing red blood cells, as well as sex- and stress-related hormones

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An early analysis of the results of 12 randomized controlled trials showed that folic acid supplementation (0.5-5 mg/day) had the greatest lowering effect on blood homocysteine concentrations (25% decrease)