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Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation

Langworth, S., et al

The precise mechanisms by which gut microbiota and its by-products affect ferroptosis remain uncertain, highlighting the need for extensive future clinical trials to explore the role of gut microbiota and its metabolites in preventing and treating IBD, as well as enhancing cellular ferroptosis

Yadav S, Gill SS, Passricha N, Gill R, Badhwar P, Anjum NA, et al

These gastrointestinal effects were generally mild and resolved upon discontinuation of therapy

Therefore, to further advance the therapeutic potential of MSC in typical or COVID-19 ARDS, more studies may be needed to focus on various aspects, including reducing cell batch heterogeneity, optimizing the dosage and administration route, and targeting the suitable patient population