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The results showed that SSA could be used as an antipyretic by reducing cAMP secretion and PKA activity in the hypothalamus ( Scutellariae Radix Scutellariae Radix (SR), known as Huangqin in Chinese, is the dried root of the Labiatae plant Scutellariae baicalensis Georgi ( + ionophore A23187 caused phosphorylation of MAPK, resulting in the activation of cytosolic phospholipase A2 (cPLA2), baicalein reduces the A23187 induced PGE2 release by inhibition of AA liberation through the inhibition of the MAPK-cPLA2 pathway

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