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When extreme cold contacts the skin, blood vessels constrict dramatically in a process called vasoconstriction

doi: 10.1016/j.cryobiol.2020.07.001

Eur J Pharmacol 17: 8796

In NSCLC, the overexpression or hyperactivation of ABC transporters, including P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRPs, such as MRP-1, MRP-2 and MRP-3) and breast cancer resistance protein (BCRP), has been closely linked to acquired resistance to multiple chemotherapeutic agents [293]

In CIRS, low VIP levels are associated with disrupted circadian biology, persistent inflammation, and impaired bloodbrain barrier (BBB) function

The video also explains the difference between preclinical findings and proven human outcomes