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NADPH oxidase directly increases and may play a central role in activating other sources of including mitochondria (via opening mitochondrial transition pore), xanthine oxidase, but activating xanthine oxidase and RNS by uncoupling both endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS

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Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease.Implications for early intervention and therapeutics

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Am J Kidney Dis 45:3947 Witko-Sarsat V, Friedlander M, Capeillre-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia

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