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Molecular Mechanisms of Action Semax Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a heptapeptide analog of the ACTH(4-10) fragment extended by the proteolysis-resistant Pro-Gly-Pro (PGP) tripeptide, acts primarily as a positive modulator of neurotrophin expression without intrinsic hormonal ACTH activity

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Elevated homocysteine has been linked to increased oxidative stress and poorer blood vessel function, which can worsen cognitive decline

Yun SJ, Lee SH, Ryu S, Choi SW, Kim HJ, Kang TK, Oh SC, Cho SJ (2018) Levodopa-carbidopa-entacapone overdose presenting as altered mental status, xanthoderma, and yellowish sclera

10.1007/s11011-022-01109-y 17 GudaP.GudaC.SubramaniamS

It binds to a receptor called TrkB on the surface of neurons