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Well, it depends on where the researcher is located

Disclosure The authors declare that they have no competing interests

Hanefeld U, Cao L, Magner E

Taken together, these findings suggest that increased BACE1 activity, i.e., increased A production, leads to the significant elevation of mtDNA mutation, which might be relevant in the onset of age-related dementia and neuropathological changes in both AD and DSAD

ELK-2A2K2E, another Apo AI mimetic peptide, is reported to restrain foam cells formation through interfering VCAM-1 expression in ECs as well as monocytes activation and infiltration 148 , which stimulates messenger RNA degradation of TNF-, MCP-1 and IL-6, and decreases their generation by modulating ABCA1/JAK2/STAT3/TTP signaling pathway 144

doi: 10.1210/en.2003-1740