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However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets

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As TPE-DCV shifts its emission wavelength upon reacting with thiols, we collect the fluorescence signals of the cell images from both green (438521 nm) and yellow channels (522581 nm)

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Front Endocrinol 10:116

The participants then underwent a second washout period where they again were allowed to go outside of the in-house facility