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84 Reduction in Nrf2 activity and a corresponding decrease in these enzymatic antioxidants have been observed in the retina of diabetic patients

NF-kB pathway modulation

The gut symbiotic microbiota enhances intestinal immune vigilance by modulating the formation and recruitment of NETs[167]
It also reduced UVB-induced inflammation and DNA damage, while promoting skin hydration and reducing melanin productionkey factors in diminishing wrinkle formation (133)
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