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Once activated, XKR8 mediates lipid scrambling, which in turn triggers Ca 2+ influx through mechanosensitive channels, providing the critical second messenger signal to propagate NET formation

PMCID: PMC3230460: 7

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This might be due to high electrostatic interaction of more positively charged nanoparticles leading to more endocytic effect [324]

From Traditional Drug Design to Catalytic Metallodrugs: A Brief History of the Use of Metals in Medicine
Gastroenterology & Hepatology 12 (4), 231242
