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Given the marked deleterious effects of circulating endotoxins, the main issues at the center of this discussion are the examination of evidence for the mechanisms of BT, i.e., how do bacteria and their endotoxins translocate across the intestine (transcellular vs

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This is a reasonable characterisation of the current literature, though it should be understood as reflecting early-stage scientific interest rather than established clinical consensus

M., Life Sci

In 1948, Rathbun first described the disease as hypophosphatasia in an infant, presented with severe bone loss, seizures, and low levels of alkaline phosphatase tissue and blood, who died of tonic epilepsy at 2 months of age [39]