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Targeting HIF-1 abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues

When examining the inclusion of Ent2 in the context of this Clathrin double mutant, we observe an increased inclusion in Abp1+ events, attributable to diminished binding from Ent1, which has now lost its main binding site

PMID 24636811

Fletcher RS, Lavery GG

there is not a body of robust human trial data showing it reliably helps patients

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