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Mubritinib has been demonstrated to suppress NADH dehydrogenase activity in a ubiquinone-dependent manner, thereby inhibiting ETC complex I and OXPHOS in AML cells

Compounds absorbed sublingually are typically small lipophilic molecules (nitroglycerin, buprenorphine) with molecular weights below 400 Da

[DOI] [PubMed] [Google Scholar] 94.Zheng JP, Kang J, Huang SG, Chen P, Yao WZ, Yang L, Bai CX, Wang CZ, Wang C, Chen BY, Shi Y, Liu CT, Chen P, Li Q, Wang ZS, Huang YJ, Luo ZY, Chen FP, Yuan JZ, Yuan BT, Qian HP, Zhi RC, Zhong NS

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MMWR Morb Mortal Wkly Rep 65: 1177, 2016

The FSP1-CoQ10 pathway suppresses ferroptosis Although we cannot sufficiently emphasize the importance of GPX4, other GPX4-independent pathways are involved in the regulation of ferroptosis