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Methylation levels of NLRP3, TGF1, MCP-1, and TNFSF2 are significantly lower in DR patients compared to healthy individuals, suggesting that hypomethylation of these genes contributes to DR progression [66]

10.1016/S0959-440X(02)00387-1 13 Business Research Insights (2023)

In addition, nicotine significantly elevated expression of PTEN (the phosphatase and tensin homolog deleted on chromosome 10), a key player in both regeneration and pain

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doi:10.1097/CRD.0000000000000513 Kruse T, Hansen JL, Dahl K, et al