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Higgins et al., 2013)

It often occurs due to viruses, infections, like tuberculosis, and certain leukemias and lymphomas

In an in vivo study performed by Frederico et al

Binding (Non-Neutralizing) Autoantibodies Mechanism: These antibodies bind to FR at sites other than the folate-binding pocket but still trigger immune-mediated damage

Subsequently, the authors determined general radiosensitivity ( D 0 dose reducing surviving fraction to 37%), quasi-threshold doses ( D q ), and extrapolation numbers ( n ) from the survival curves and correlated these parameters with the cellular levels of GPx, catalase, CuZn superoxide dismutase (Cu/Zn-SOD), and Mn superoxide dismutase (Mn-SOD)

Pittevils et al