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However, some natural compounds, such as 8 alkaloids [berberine hydrochloride (Zhu et al., 2019a), berberrubine (Yu et al., 2018), coptisine (Wang et al., 2021a), dihydroberberine (Li et al., 2021), evodiamine (Shen et al., 2019), matrine (Yan et al., 2020), nigakinone (Liu et al., 2023), and piperine (Qu et al., 2021), licochalcone A (Zhang et al., 2021), licoflavone B (Zhang et al., 2022b), phloretin (Zhang Z