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Altogether, this review presents an overview of the rapid progress that has been made turning a technique, proposed just a few decades ago, into a viable clinical method for safe, targeted delivery of CNS therapeutics

For instance, the combination of ARS-1620 with SHP-099, an SHP2 inhibitor, significantly reduced tumour volume in tumour models with KRAS (G12C) 170,177

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However, there are also doubts about the effectiveness of fingolimod treatment in the brain injury context

This reaction is catalyzed by glutamate decarboxylase (GAD), which is encoded by two different genes, GAD1 and GAD2 in humans ( Gad1 and Gad2 in rodents)