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While Y chromosome loss is not associated with changes in tumor growth, tumor grade, and tumor stage of bladder tumors, specifically [100], recent work shows that deletion of the Y chromosome by CRISPRCas9 contributes to immune dysfunction in the TME and better response to immune checkpoint blockade [101]

Efferocytosis occurs through four major steps: Find-Me, Eat-Me, engulfment/digestion, and anti-inflammatory responses. Find-Me signals, varying according to the type of injury and the tissue [31], are released by dead cells

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