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Most of the oxygen consumed by humans is metabolized within the mitochondria

Late diagnosis is one of the major concerns

Furthermore, hypoxia-induced endogenous LOX expression has been applied in the repair of de novo multiple musculoskeletal tissues (i.e., cartilage, meniscus, tendons, and ligaments) as important regenerative strategies, which is mainly mediated through mechanisms of hypoxia-induced enhanced PYR crosslinking and increased tensile properties of collagen-rich tissues (Makris et al., 2014)

Vitamin E (200 mg thrice daily for 4 weeks) demonstrated significant improvement in a limited case series

Keywords: Metformin, Vitamin B 12 deficiency, Diabetes mellitus, Vitamin B12, Type 2 diabetes mellitus Core Tip: In the last 20 years, there was increasing evidence of the presence of vitamin B12 deficiency among metformin-treated diabetic patients