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10.1016/S2213-2600(20)30079-5 3

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These include altered choline metabolism, changes in neurotransmitter metabolism, defective DNA methylation with consequent poly (ADP-ribose) polymerase (PARP) overactivation and PARP-controlled cell death, excitotoxicity, up-regulation of re-entry to the cell division cycle, hypomethylation of myelin lipids and myelin basic protein, white matter changes, and the formation of homocysteine thiolactone and subsequent protein homocysteinylation (89)

This defense is not available for people who have previous convictions under certain drug laws, people who have already used the defense in the past and people who have called 911 for a possible overdose in the last 18 months

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