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Strikingly, vitamin D receptor was demonstrated to be key in the control of liver fibrosis by affecting SMAD3-mediated transcriptional response in mouse model, supporting the notion that this pathway might be essential in the control of liver fibrosis (Ding et al., Together these studies confirm that genetics may play a critical role in influencing disease progression independently of the cause of the fibrosis (Mendelian or infectious disease)

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